- 作者: Deeb, A. ; Said, S.A. ; Hamed, M.M. et al.
- 作者服務機構: Dept. of Chemistry, Zagazig Univ., Zagazig Egypt
- 中文摘要: 4-Cyano-5,6-diphenyl-2,3-dihydropyridazine-3-one 1 reacts with phosphorous oxychloride to give 70% of the corresponding 3-chloro derivative 2. Treating 2 with anthranilic acid in butanol, 4-cyano-2,3-diphenyl-10H-pyridazino(6,1-b)quinoxaline-10-one was obtained. Compound 1 reacts with phosphorous pentasulphide to give 3-mercapto derivative 4, which was converted by acrylonitrile to the S-(2-cyanoethyl)pyridazine derivative. Compound 4 reacts with ethyl bromoacetate and with phenacyl bromide gave the corresponding thieno(2,3-c)pyridazine derivatives. Alkylation of 1 with ethyl chloroacetate afforded 3-0-carbethoxymethyl derivative 10. Compound 10 reacts with amines (aniline, hydrazine) to give the corresponding amide and acid hydrazide respectively. Hydrolysis of 10 with sodium hydroxide gave the corresponding acid derivative. Treating 1 with methyl iodide, 3-0-methyl derivative was obtained, which was converted by ammonium acetate/acetic acid to 3-amino-4-cyano-5,6-diphenyl pyridazine. Compound 1 reacts with methyl magnesium iodide gave the 4-acetyl derivative, which was reacted with hydrazine, phenyl hydrazine and with hydroxylamine to give the substituted 1H-pyrazolo(3,4-c) pyridazine and isoxazolo(5,4-c) pyridazine derivatives respectively.
- 英文摘要: --
- 中文關鍵字: 3-Chloro-4-Cyano-5,6-Diphenylpyridazine; Anthranilic Acid; Phosphorus Pentasulfide; Ethyl Bromoacetate; Phenacylbromide; 1H-Pyrazolo
- 英文關鍵字: 3-氯-4-氰-5;6-二苯基嗒;鄰胺基苯甲酸;五硫化二磷;溴乙酸乙酯;苯甲醯溴甲烷;1氫-唑(3;4-c)嗒;異噁唑(5;4-c)嗒