- 作者: Haroon Rashid, Syed Qaiser Shah*
- 作者服務機構: Department of Chemistry, University of Peshawar, Peshawar-25120, Pakistan
- 中文摘要: 99mTc-Tin-nano colloid is a radiopharmaceutical that can be useful in evaluation of the patients with breast cancer. The current method for preparation requires a lengthy boiling water bath procedure, and the recommended quality control procedure is cumbersome and time consuming. Using a microwave oven, the heating time necessary to provide a maximum labeling efficiency has been reduced to 10 second. A new mini paper chromatography (MPC) system has been developed to analyze the radiochemical purity (RCP) of the labeled preparation involving two different developing solvents. The recommended thin layer chromatography (TLC) system involving the use of an Al2O3 coated plate requires an average time for drying and development of 34.5 ± 0.44 min (n = 30) to complete, whereas the new MPC system has an average developing time of 2.1 ± 0.2 min (n = 20). For RCP values the MPC and TLC methods are correlated closely (r = 0.94). The combined use of the microwave oven heating method and over quick quality control system will facilitate the rapid emergency use of 99mTc-Tin-nano colloid.
- 英文摘要: --
- 中文關鍵字: Radiochemical purity; Mini paper chromatography and Thin layer chromatography.
- 英文關鍵字: --