• 作者： 王夢嵐
• 作者服務機構： 國防醫學院
• 中文摘要： 利用注射硝基甲烷後產生組織膠酸血症的動物，來探討其腦中游離胺酸的代謝情形，以及大腦切片培養對放射性先質的攝取與代謝的情形“ 組織胺酸血症動物之腦中游離胺酸之變化，除了組織胺酸的含量比對照高三倍外，其餘的胺基酸的含量與對照組相比較無統計上的差異。腦中蛋白質的含量亦無改變。在腦中測不出有組織胺酸去氨?及組識胺酸轉氨?的存在。 將腦切片做組識培養實體時，發現組織胺酸血症動物之腦組織切片對放射性葡萄糖及尿嘧啶核?之吸收與代謝與對照組相比較無顯著的差異，但對放射性組織胺酸的攝取有顯著的抑制現象。
• 英文摘要： Histidinemic rats was produced by injection of nitromethane. Thealteration of brain amino acid concentrations and the incorporation oflabeled precursor in. brain slices were investigated'. Except histidine, there were no significant alterations of the aminoacid patterns in the brain. Histidine concentration in brain was increasedto a plateau of 3-fold of the controls after 6 days injection of nitromethane.There were no measurable histidase and histidine}pyruvate aminotransferaseactivity in the brain. The protein contents showed no significant differencebetween. histidinemic ratsand controls: Incorporation of Glu-6-3H into brain lipid, protein, RNA and DNA wasnot impaired. The incorporation of Uridine-3H into brain protein was notchange too. The uptake of Histidine-14C by brain slices was greatly decreasedin histi dinemic rats. These results: showed that only the uptake of histidinewas affected by the high concentration of histidine in brain: The mechanism:of brain function impairment in histidinemia still awaits further investigation:
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