- 作者: Hyung-Sik Kang Dae-Ho Cho Sung-Sook Kim Kwang-Ho Pyun Inpyo choi
- 作者服務機構: Immune cell Signal Transduction Reserch Unit, Korea Reserch Institute of Bioscience and Biotechnology, Taejon, and Department of Pathology, Ulsan Unlversity Hospital, Ulsan, Republic of KOrea
- 中文摘要: --
- 英文摘要: IL-6 is a pleiotropic cytokine that is capable of modulat-ing the diverse functions of hepatocytes such as acutephase responses and inflammation in the liver. To learnits antitumor effects in vivo, the cDNA of IL-6 was trans-fected into murine liver cells, TIB cells. IL-6-transfectedTIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higherlevels of IL-6 compared with vector-transfected TIB cells(TIB73-vec or TIB75-vec). To investigate the effects of IL-6on TIB tumor growth in vivo, IL-6-transfected TIB cells orvector-transfected TIB cells were injected subcutaneous-1y into syngeneic mice. Vector-transfected TIB cells grewrapidly 3 weeks after injection, but IL-6-transfected TIBcells did not grow at all for up to 6 weeks. Pathologically,IL-6-transfected TIB cells demonstrated a severe necrosisand apoptotic pattern. Taken together, these results indi-cate that IL-6 functions as a growth inhibiting factor invivo, and another biological role of IL-6 in the liver is sug-gested.
- 中文關鍵字: --
- 英文關鍵字: Liver tumor. Interleukin-6. Antitumor effects. Host immunity