- 作者: 林明正,賴靜雯,林中生,林家立
- 作者服務機構: Department of Chemistry, National Chung-Hsing University, Taichung 402, Taiwan, R.O.C.
- 中文摘要: The goal of this work was to determine the reaction mechanism for Pseudomonas species lipase activation by cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride based on the results from enzyme kinetics. These drugs are the essential activators of Pseudomonas species lipase in the presence of triton-X 100 or taurochloate in vitro. Moreover, QSAR studies show that the pKA values are correlated with the molecular weights of these drugs.
- 英文摘要: --
- 中文關鍵字: Lipase; Enzyme kinetics; Cardiovascular drug; Enzyme activation.
- 英文關鍵字: --