• 作者： Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen
• 作者服務機構： 1.Institute of Biomedical Sciences, Academia Sinica, 128 Academia Rd. Sec. 2, Taipei, 115, Taiwan 2.Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan 3.Department of Neurology, Kaohsiung Medical University Hospital; Kaohsiung Medical University, Kaohsiung, Taiwan 4.PhD program in Translational Medicine, Kaohsiung Medical University and Academia Sinica, Taipei, Taiwan 5.Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan 6.Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan 7.PhD program in Translational Medicine, Kaohsiung Medical University and Academia Sinica, Taipei, Taiwan 8.Taiwan Mouse Clinic – National Comprehensive Mouse Phenotyping and Drug Testing Center, Academia Sinica, Taipei, Taiwan
• 中文摘要：
• 英文摘要：
  Background
  Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.
  
  Main body
  In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called “sngception (sng- ception)” to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. “Sng” is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore.
  
  Conclusion
  Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.
• 中文關鍵字：
• 英文關鍵字： Acidosis, ASIC3, Nociception, Pain, Sngception, Soreness