• 作者： 林仁壽; 謝美華; 吳兩新; 林文翰
• 作者服務機構： 國立臺灣大學畜牧學系; 臺中榮民總醫院新陳代謝科
• 中文摘要： 本研究選用Wistar系，體重200-250公克之雄性大鼠為材料，以Alloxan誘發糖尿病後，檢查其腎上腺皮質功能。
  結果發現，大鼠經Alloxan注射後，一週內其腎上腺分泌腎皮酮能力顯?受到抑制。經體外與體內各項試驗，進一步證
  實此抑制作用，係因Alloxan直接破壞腎上皮細胞(Adrenal cortex cells)所致，非因血糖驟增引起。此外，Streptozo-
  tocin亦有直接破壞腎上腺皮質細胞之效應。
  尚
• 英文摘要： The purpose of this study is to investigate the adrenocortical function of alloxan-induced diabeticrats. Male rats of Wistar strain, weighing 200-250 gm were used. The results indicated that the adrenocor-tical response to stress and exogenous corticotropin (ACTH )is decreased during the early diabeticstages (up to 6 days). Evidence from in vivo and in vitro studies shows that the depression is caused by thetoxicity of alloxan on the adrenal cortex cells and not by the sudden rise of blood glucose levels. Strepto-zotocin (another diabetogen) has the same effect as alloxan on adrenal cortex cells.
• 中文關鍵字： adrenocortical function; glucose; alloxn; streptozotocin; diabetic; rat.
• 英文關鍵字： --