• 作者： 劉雨田; 李雪煇
• 作者服務機構： 國防醫學院微生物及免疫學科
• 中文摘要： Gluconobacter oxydan CCRC 10383可將7-amino-3-desacetoxycephalosporanic acid (7-ADCA)和D-a-phenylgly-cine tnethylester HCl (PGM)合成為cephalexin。一些影響G. oxydans CCRC 10383生產cephalexin的因素已被研究。最適合cephalexin之合成反應的pH值和溫度分別為6.0和42°C。在PGM濃度高於7-ADCA濃度的條件下可獲得較高的ce-phalexin產量。
• 英文摘要： Intact cells of Gluconobacter oxydans CCRC 10383 produced cephalexin from 7-amino-3-deacetoxycephalosporamc acid (7-ADCA) and D-α-phenylglycine methylester HC1 (PGhl). Factors affecting theproduction of cephalexin by G. oxydans CCRC 10383 were studied. The optimum pH and temperaturefor the synthetic reaction of cephalexin were 6.0 and 42°C, respectively. A higher concentration of PGMthan 7-ADCA was required to obtain a good yield of cephalexin.
• 中文關鍵字： cephalexin; Gluconobacter oxydans; 7-ADCA.
• 英文關鍵字： --