- 作者: Meng-Yang Chang and Shui-Tein Chen
- 中文摘要:
Institute of Biological Chemistry, Academia Sinica, Taiwan
The total synthesis of the non-peptide fibrinogen receptor antagonists, sibrafiban (1) (Ro 48-3657) and lamifiban (2) (Ro 44-9883), is described. Both contain 4-hydroxypiperidine unit and the same solid-phase synthesis method was used as a key step. Connection of a secondary alcohol to the DHP-resin, followed by iterative saponification and coupling sequences, provided novel drugs. - 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --