- 作者: Ran You, Yuen-Shan Ho & Raymond Chuen-Chung Chang
- 作者服務機構: 1.Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, Pokfulam, Hong Kong SAR, China 2.Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China 3.School of Nursing, Faculty of Social and Health Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China 4.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
- 中文摘要:
- 英文摘要:
The increasing amount of particulate matter (PM) in the ambient air is a pressing public health issue globally. Epide‑
miological studies involving data from millions of patients or volunteers have associated PM with increased risk of
dementia and Alzheimer’s disease in the elderly and cognitive dysfunction and neurodegenerative pathology across
all age groups, suggesting that PM may be a risk factor for neurodegenerative diseases. Neurodegenerative diseases
afect an increasing population in this aging society, putting a heavy burden on economics and family. Therefore,
understanding the mechanism by which PM contributes to neurodegeneration is essential to develop efective
interventions. Evidence in human and animal studies suggested that PM induced neurodenegerative-like pathology
including neurotoxicity, neuroinfammation, oxidative stress, and damage in blood–brain barrier and neurovascular
units, which may contribute to the increased risk of neurodegeneration. Interestingly, antagonizing oxidative stress
alleviated the neurotoxicity of PM, which may underlie the essential role of oxidative stress in PM’s potential efect in
neurodegeneration. This review summarized up-to-date epidemiological and experimental studies on the pathogenic
role of PM in neurodegenerative diseases and discussed the possible underlying mechanisms. - 中文關鍵字:
- 英文關鍵字: Particulate matter, Neurodegeneration, Alzheimer’s disease, Cognitive dysfunctions, Oxidative stress, Neuroinfammation