- 作者: Hong-Ru Chen, Yen-Chung Lai and Trai-Ming Yeh
- 作者服務機構: 1. The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2. Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- 中文摘要:
- 英文摘要:
Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic symptoms of DHF/DSS. However, due to the limited understanding of dengue pathogenesis, no satisfactory therapies to treat nor vaccine to prevent dengue infection are available, and the mortality of DHF/DSS is still high. DENV nonstructural protein 1 (NS1), which can be secreted in patients’ sera, has been used as an early diagnostic marker for dengue infection for many years. However, the roles of NS1 in dengue-induced vascular leakage were described only recently. In this article, the pathogenic roles of DENV NS1 in hemorrhage and vascular leakage are reviewed, and the possibility of using NS1 as a therapeutic target and vaccine candidate is discussed. - 中文關鍵字:
- 英文關鍵字: Dengue virus (DENV), Nonstructural protein 1 (NS1), Hemorrhage, Coagulopathy, Vascular leakage, Vaccine