- 作者: 陳介甫; 鄭麗貞; 廖志飛; 周先樂
- 作者服務機構: 國立陽明醫學院藥理學科; 榮民總醫院醫學研究部
- 中文摘要:
本研究以不同的實驗性癲癇模式,觀察 Ketamine 之抗抽搐作用或加強抽搐發作之作用,而
發現:
1. Ketamine 於低於麻醉劑量時,對小白鼠因音饗及電刺激所誘發之抽搐現象有保護作
用。
2. Ketamine 對小白鼠因化學藥品 (Pentylenetetrazol 或 Strychnine) 所誘發之抽搐現象
,於低於麻醉劑量時並無抗抽搐作用。
3. Ketamine 加強大白鼠由於右額葉植鈷所誘發之不正常腦電波,但當此不正常腦電波過
於劇烈時,Ketamine反而抑制此癲癇性腦電波之傳播。
4. Ketamine 並非碳酸酐?抑制劑。
內 - 英文摘要: Anticonvulsive or seizure inductive effectsof ketamine were studied in different experi-mental epilepsy models. It was found that: 1 .Ketamine in subanesthetic does protectedthe animal against audiogenic seizures and ma-ximal electroshock seizures in mice. 2. Ketamine, at subanesthetic dose, has noanticonvulsive effects in chemically (Pentylene-tetrazol or Strychnine) induced seizures in mice. 3. Ketamine enhanced the abnormal electro-corticogram (ECoG) induced by cobalt implan-tation in the right frontal cortex of rats; how-ever, it inhibited the spread of epileptogenicactivity when the abnormal ECoG was severe. 4. Ketamine was not a carbonic anhydraseinhibitor.
- 中文關鍵字: --
- 英文關鍵字: --