- 作者: Ping-Chia Li; I-Ju Lai; Yu-Ching Lin; Li-Ching Chang; Wen-Chung Chen
- 作者服務機構: Department of Occupational Therapy, I-Shou University, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Background :
Airborne particulate matter, from cooking oil, smoking, engine exhaust and other
sources, is associated with the development of atherosclerosis and myocardial
infarction. In order to explore the cellular and molecular events following exposure of
rats to lard oil smoke, we measured the generation of reactive oxygen species (ROS),
substance P, cellular adhesion molecules, and thrombosis in relation to inhibitors of
substance P, the NK-1 receptor, and antioxidants.
Methods :
Rats were exposed to oil smoke for 120 min with or without 20 min pretreatment with
lovastatin (substance P scavenger), L733060 (NK-1 receptor antagonist), vitamin E
(antioxidant) or catechins (antioxidant). The levels of substance P and ROS were
measured. Histological studies observed ROS damage in the form of HEL adducts.
The prothrombotic effects of oil smoke exposure were measured by experimental
induction of thrombosis in vivo.
Results :
Oil smoke exposure significantly increased substance P levels, ROS levels, ROS
damage (HEL adduct levels), and the size of experimentally induced thrombi. The
pretreatments reduced all of these effects of oil smoke exposure; at many time points
the reductions were statistically significant.
Conclusions :
We established a connection between oil smoke exposure and thrombosis which
involves substance P and its receptor, the NK-1 receptor, and ROS. This study helps establish a mechanistic explanation of how airborne particulate matter can increase
the risk of cardiovascular illness. - 中文關鍵字: --
- 英文關鍵字: --