- 作者: 林烈生; 邱文達; 林茂村; 施純仁
- 作者服務機構: 馬偕紀念醫院神經外科; 成大醫學院生理學科
- 中文摘要: 在本實驗中,我們施行大白鼠的上頸神經節之節前神經切斷術並觀測多種生理功能與不同腦區單胺類物質含量之變化。在環境溫度八至三十度(攝氏)中,這些經過交感神經祛除後的大白鼠仍舊保有與正常鼠一樣的體溫調節能力。這些動物的自發性痛閾與運動能力與正常者無異。然而,與正常動物相比,這些交感神經祛除後的動物對於嗎啡止痛與安非它命增進運動活力的作用皆有顯著的增強作用。生化檢驗結果顯示這些交感神經祛除鼠的下視丘單胺類物質(包括妥巴胺、去甲基腎上腺素與五羥色胺)含量以及紋狀體內的妥巴胺含量皆明顯的增加。由本結果推論:在交感神經祛除狀況之下,不同腦區單胺類物質含量之變化可能導致上述所見到的生理功能之異常。
- 英文摘要: In the present study, we conducted pre-ganglionic decentralization (or sympathetic trunk resection)of the superior Cervical ganglia and observed alterations in several physiological functions and in the mono-amine content of different brain regions. Over an ambient temperature range of 8-30℃, these sympathec-tomized rats maintained their rectal temperatures within a normal limit displayed by the intact controls.These sympathectomized animals, although showing no change in the level of spontaneous pain thresholdor motor activity, did display an increased sensitivity of analgesic responses to morphine administration orlocomotor stimulant responses to amphetamine administration. Biochemical examination revealed thatthese sympathectomized animals had a higher level of norepinephrine, dopamine or 5-hydroxytryptaminein the hypothalamus, as well as a higher level of dopamine in the corpus striatum. However, in the brain-stem, these sympathectomized animals had a unaltered monoamine level. The data indicate that, in a sym-pathectomized condition, changes in the monoamine content of different brain regions may be correlatedwith the above-mentioned alterations in somatosensory and motor neural functions.
- 中文關鍵字: sympathectomy; sympathetic ganglia; thermoregulation; antinociception; motor activity; brain monoamines
- 英文關鍵字: --