- 作者: 田添,曹玲華
- 作者服務機構: College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi, Xinjiang, 830046, P. R. China
- 中文摘要: The starting material O-protected glycosyl isothiocyanate (1~3) was refluxed with 1,4-diaminobenzene in CHCl3 under nitrogen atmosphere to give 1,4-bis(N-glycosyl)thioureidobenzene (4~6). Then 1,4-bis[N-(4/6-substituted benzothiazole-2-yl)-N'-glycosylguanidino]benzenes (8a~8e, 9a~9e, 10a~10e) were obtained in good yield by reaction of compounds (4~6) with 2-amino-4/6-benzothizoles (7a~7e) and HgCl2 in the presence of TEA in DMF. The structures of all 18 new compounds were confirmed by IR, 1H NMR, LC-MS and elemental analysis. The bioactivity of anti-HIV-1 protease (HIV-1 PR) and against angiotensin converting enzyme (ACE) have been evaluated.
- 英文摘要: --
- 中文關鍵字: Glycosyl isothiocyanate; 1,4-Diaminobenzene; Benzothiazole; Glycosylguanidine.
- 英文關鍵字: --