- 作者: W. Gibson Wood Nicolai A. AVdulov Svetlana V. Chochina Urule lgbavboa
- 作者服務機構: Geriatric research, Education and Clinical Center, VA Medical Center, and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, Minn., USA
- 中文摘要: --
- 英文摘要: Ethanol has a pronounced effect on lipid homeostasis. Itis our overall hypothesis that certain lipid carrier proteinsare targets of acute and chronic ethanol exposure andthat perturbation of these proteins induces lipid dysfunc-tion leading to cellular path ophysiology. These proteinsinclude both intracellular proteins and lipoproteins. Thispaper examines recent data on the interaction of ethanolwith these proteins. In addition, new data are presentedon the stimulatory effects of ethanol on low-density-lipo-protein (LDL)-mediated cholesterol uptake into fibro-blasts and direct perturbation of the LDL apolipoprotein,apolipoprotein B. A cell model is presented that outlinespotential mechanisms thought to be involved in ethanolperturbation of cholesterol transport and distribution.
- 中文關鍵字: --
- 英文關鍵字: Alcoholism. Apolipoproteins. cardiovascular disease. Cholesterol. Ethanol. High-density lipoproteins. Lipids. Low-density lipoproteins. reverse cholesterol transport