- 作者: Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang
- 作者服務機構: School of Medicine, Nankai University, Tianjin, China
- 中文摘要: --
- 英文摘要:
Background Nanomaterials, as a new kind of materials, have been greatly applied in
different fields due to their special properties. With the industrialization of nanostructured
materials and increasing public exposure, the biosafety and potential influences on central nervous
system (CNS) have received more attention. Nanosized zinc oxide (nanoZnO) was suggested to
up-regulate neuronal excitability and to induce glutamate release in vitro. Therefore, we
hypothesized nanoparticles of nanoZnO may lead to changes in balance of neurotransmitter or
neuronal excitability of CNS. This study was to investigate if there were effects of nanoZnO on
animal model of depression. Methods Male Swiss mice were given lipopolysaccharides (LPS,
100μg/kg, 100μg/ml, every other day, 8 times, i.p.) from weaning to induce depressive-like
behaviors. NanoZnO (5.6 mg/kg, 5.6mg/ml, every other day, 8 times, i.p.) was given as the
interaction. The mouse model was characterized using the methods of open field test, tail
suspension test and forced swim test. Furthermore, the spatial memory was evaluated using Morris
water maze (MWM) and the synaptic plasticity was assessed by measuring the long-term
potentiation (LTP) in the perforant pathway (PP) to dentate gyrus (DG) in vivo. Results Results
indicated that model mice showed disrupted spatial memory and LTP after LPS injections and the
behavioral and electrophysiological improvements after nanoZnO treatment. Conclusion Data
suggested that nanoZnO may play some roles in CNS of mental disorders, which could provide
some useful direction on the new drug exploring and clinical researches. - 中文關鍵字: --
- 英文關鍵字: Morris water maze; long-term potentiation; depression; hippocampus; nanoparticles zinc oxide (nanoZnO)