- 作者: Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang and Yunfu Cui
- 作者服務機構: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, No.246 XueFu Avenue, Harbin, Heilongjiang Province, China
- 中文摘要:
- 英文摘要:
Background
Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease.
Main body of the abstract
Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA. This work summarize current evidence regarding the biological functions and underlying mechanisms of lncRNA MIAT during disease development.
Short conclusion
LncRNA MIAT likely represents a feasible cancer biomarker or therapeutic target. - 中文關鍵字:
- 英文關鍵字: Long non-coding RNA, LncRNA, MIAT, Diseases