• 作者： 彭明聰; 江美治
• 作者服務機構： 國立臺灣大學醫學院生理學科
• 中文摘要： 使用39隻不同年齡（4個月至33個月）Long-Evans 雄鼠檢查一日活動量、食量及喝水量，並日間與夜間分別記錄。年齡愈大，活動及食量愈減少，喝水量在4個月至17個月範圍內，年齡愈大愈減少，但17個月以後年齡愈大則愈增加。年輕鼠（4個月至7個月）其夜間活動占全日活動為 81%，食量為 67%，喝水量為 74%，12個月以上者，此等比率年齡愈大逐漸減少，而日夜間差別消失者活動有 6%（20隻中1隻），食量有 18%（22隻中4隻），喝水量有 9%（22隻中2隻）。照光時間顛倒後年輕鼠活動，食量及喝水量的日夜差各 6.2日，9.4日及 8.5日後恢復。12個月以上雄鼠活動的日夜差18隻中1隻，食量的日夜差17隻中2隻，14日後亦不 恢復外，其他雄鼠活動、食量及喝水量的日夜差恢復所需日數與年輕鼠並無差別。日夜差消失者，夜間占全日減少者，或照光時間顛倒日夜差不恢復者之視徑交叉上核之神經細胞數有何變化，現正在測量中，尚未完畢。以上結果表示雄鼠年老時之活動、食量及喝水量之日夜差或照光顛倒後，此等日夜差恢復的能力尚相當良好。
• 英文摘要： Running-wheel activity, food intake andwater intake of 39 male Long-Evans rats ofvarious age ranged from 4- to 33-month-old,were recorded twice a day and total activity orintake per day, and percentage nocturnal activitywere studied. Running activity and food intakedecrease as age advances and water intake de-creases from 4-month-old to 17-month-old, andlater on water intake increased proportionallywith increase of age. The percentage nocturnalactivity of running-wheel, food intake and waterintake decreases from 12-month-old propor-tionally with increase of age. Disappearanceof diurnal difference was observed in 1 out of20 rats over 12-month-old in running activity,4 out of 22 rats in food intake, 2 out of 22 ratsin water intake. Low percentage nocturnalactivity was noted in 2 out of 20 rats in runningactivity, 5 out of 22 rats in food intake and 4out of 22 rats in water intake. When light-dark schedule is reversed, youngadult rats (4- to 7-month-old) recover theircircadian rhythm with a period of 6.2 days, 9.4days and 8.5 days in running activity, food intakeand water intake respectively. Except 1 out of18 rats over 12-month-old in running activityand 2 out of 17 rats in food intake, all of ratsover 12-month-old can recover their circadianrhythm with a period not significantly differentfrom young adult rats. These results indicatethat the ability to keep the circadian rhythmof running activity, food intake and water intakeor the ability to recover the circadian rhythmwhen light-dark schedule is reversed, are stillpreserved in old age in most rats. Counting of neuron number of the sup-rachiasmatic nucleus in the rats which lost thecircadian rhythm, showed low percentagenocturnal activity or lost the ability to recoverthe circadian rhythm when light-dark scheduleis reversed, is still in progress.
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