- 作者: Robert E. Kramer, Susan E. Wellman, Robin W. Rockhold, Rodney C. Baker
- 作者服務機構: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Miss., USA
- 中文摘要: --
- 英文摘要: administration (6.25-25 mg/kg), methyl parathion con-centrations peaked within 12-26 h and then declineddose dependently. The apparent dermal absorption coef-ficient was approximately 0.41 h , and only two phar-macokinetic compartments could be distinguished. Inconclusion, the pharmacokinetics of methyl parathionare complex and route dependent. Also, dermal expo-sure, because of sustained methyl parathion concentra-tions, may pose the greatest risk.Assessment of the risks posed by the residential use ofmethyl parathion requires an understanding of its phar-macokinetics after different routes of exposure. Thus,studies were performed using adult female rats to definethe pharmacokinetic parameters for methyl parathionafter intravenous injection and to apply the describedmodel to an examination of its pharmacokinetics aftersingle oral or dermal exposure. The pharmacokineticsof methyl parathion after intravenous administration(1.5 mg/kg) were best described by a three-compartmentmodel; the apparent volume of the central compartmentwas 1.45 liters/kg, clearance was 1.85 liters/h/kg and theterminal half-life was 6.6 h with an elimination constantof 0.50 h . The apparent oral absorption coefficient formethyl parathion (1.5 mg/kg) was 1.24 h , and its oralbioavailability was approximately 20%. The latter likelyincludes a significant first pass effect. Concentrations ofmethyl parathion increased during the initial 10-60 minand then declined during the next 15-36 h. After dermal
- 中文關鍵字: --
- 英文關鍵字: Rat, Acetylcholinesterase, Methyl parathion, Methyl paraoxon, Pharmacokinetics, Organophosphorus insecticides