- 作者: Fedor Simko; Vaclav Pelouch; Jozef Torok; Ivan Luptak; Jana Matuskova; Olga Pechanova; Pavel Babal
- 作者服務機構: 1 Department of Pathophysiology and 3rd Clinic of Medicine, Comenius University, School of Medicine, Bratislava, Slovak Republic; ; 2 Department of Medical Chemistry and Biochemistry, 2nd Faculty of Medicine, Charles University, and Centre for Experimental Cardiovascular Research, Prague, Czech Republic;; 3 Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic;; 4 Department of Pathology, Comenius University, School of Medicine, Bratislava, Slovak Republic
- 中文摘要: --
- 英文摘要: The aim of this study was to determine whether protein remodeling of the heart ventricles and remodeling of the aorta were present in hereditary hypertriglyceridemic (hHTG) rats and whether treatment with the angiotensin-converting enzyme inhibitor, captopril, could prevent these alterations. Three groups of rats were investigated in a four week experiment: control Wistar /C/rats, hHTG rats, and hHTG rats given captopril (100 mg/kg/day) (hHTG + Cap). In the hHTG group, the increased systolic blood pressure (SBP) was associated with hypertrophy of the LV and RV. Protein profile analysis revealed an enhancement of metabolic protein concentration in both ventricles. The concentration of total collagenous proteins was not changed in either ventricles. However, alterations in composition of cardiac collagen were detected, characterized by higher concentration of hydroxyproline in pepsin-insoluble fraction and lower concentration of hydroxyproline in pepsin soluble fraction in the LV. Hypertrophy of aorta, associated with the reduction of nitric oxide dependent relaxation, was also present in hHTG rats. Captopril normalized SBP, reduced left ventricular hypertrophy (LVH), diminished metabolic protein concentration in both ventricles, and improved NO-dependent relaxation of the aorta. Furthermore, captopril partially reversed alterations in hydroxyproline concentration in soluble and insoluble collagenous fractions of the LV. We conclude that hypertrophy of both ventricles and the aorta is present in hHTG rats, along with protein remodeling of both ventricles. Captopril partially prevented left ventricular hypertrophy development and protein remodeling of the myocardium.
- 中文關鍵字: --
- 英文關鍵字: ACE-inhibition, collagen, hereditary hypertriglyceridemic rat, protein remodeling, vascular relaxation