- 作者: Victor Hesselbrock Henri Begleiter Bernice Porjesz Sean O'connor Lance Bauer
- 作者服務機構: Department of Psychiatry, University of Connecticut School of MEdicine, Farmington, Conn., USA
- 中文摘要: --
- 英文摘要: There is substantial information supporting the role ofgenetic factors in the susceptibility for alcohol depen-dence. However, the identification of specific genes thatcontribute to this predisposition has proven elusive,although several theoretically relevant candidates, e.g.DRD2 or 5-HT , have been considered. The difficulty inidentifying specific genes may be related to the clinicalheterogeneity of the disorder resulting in a poorly de-fined phenotype for genetic analysis. An alternative ap-proach to the use of a diagnostic phenotype for identi-fying alcoholism susceptibility genes may lie in theexamination of the neurobiological correlates of the dis-order, the so-called endophenotypes. One possible en-dophenotype of alcohol dependence may be related tothe P waveform of the event-related brain potential(ERP). Using data obtained from the Collaborative Studyon the Genetics of Alcoholism (COGA), a multi-site fami-ly-based study, the utility of P3oo amplitude as an endo-phentype was examined. Differences in P amplitudewere found between alcoholics and nonalcoholics, be-tween unaffected relatives of alcoholics and relatives ofcontrols, as well as between unaffected offspring of alco-holic fathers and offspring of controls. A genetic analysisindicated that attributes of the P ERP waveform are her-itable, and a quantitative trait locus analysis found link-age to several chromosomal regions. These data providesignificant support for P as an endophenotype foralcohol dependence.
- 中文關鍵字: --
- 英文關鍵字: Alcohol dependence. Event=Related potentials. Endophenotype. Genetics. Electrophysiology