- 作者: Marcella Martinelli, Luca Scapoli, Francesca Cura, Maria Teresa Rodia, Giampaolo Ugolini, Isacco Montroni , Rossella Solmi
- 作者服務機構: Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Belmeloro, Bologna, Italy
- 中文摘要: --
- 英文摘要:
Background:
The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product represents a barrier against xenobiotics, bacterial toxins, drugs and other substances introduced with diet, including carcinogens. The aim of this investigation
was to verify the possible contribution of ABCB1 single nucleotide polymorphisms (SNPs) to the genetic risk of colorectal cancer (CRC).
Results:
DNA obtained from the peripheral blood of 98 CRC patients and 100 healthy controls was genotyped for the three selected SNPs: 1236C > T (rs1128503), 2677G > T/A (rs2032582), and 3435C > T (rs1045642). Molecular data were analyzed to asses allele and haplotype association with CRC.
No evidence of an association between ABCB1 alleles and CRC occurrence as a whole was found. However, ABCB1 showed either association with carcinoma of the sigmoid colon, and appeared able to influence the sex ratio among CRC patients. These two effects seemed to act independently basing on multivariate analysis. We showed that ABCB1 polymorphisms were able to influence CRC susceptibility related to tumor localization and patient gender.
Conclusions:
We could suggest that sensitivity to undetermined risk factors could depend on the genetic background of ABCB1 locus, with a mechanism that also depends on patient gender. - 中文關鍵字: --
- 英文關鍵字: Colorectal cancer, ABCB1 gene, Polymorphism, Association analysis