- 作者: José Antônio Fagundes Assumpção, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martín Hernan Bonamino & Kelly Grace Magalhães
- 作者服務機構: 1.Immunology and Tumor Biology Program - Research Coordination, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil 2.Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil 3.Vice - Presidency of Research and Biological Collections (VPPCB), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
- 中文摘要:
- 英文摘要:
Obesity is nowadays considered a pandemic which prevalence’s has been steadily increasingly in western countries.
It is a dynamic, complex, and multifactorial disease which propitiates the development of several metabolic and car‑
diovascular diseases, as well as cancer. Excessive adipose tissue has been causally related to cancer progression and is
a preventable risk factor for overall and cancer-specifc survival, associated with poor prognosis in cancer patients. The
onset of obesity features a state of chronic low-grade infammation and secretion of a diversity of adipocyte-derived
molecules (adipokines, cytokines, hormones), responsible for altering the metabolic, infammatory, and immune land‑
scape. The crosstalk between adipocytes and tumor cells fuels the tumor microenvironment with pro-infammatory
factors, promoting tissue injury, mutagenesis, invasion, and metastasis. Although classically established as a risk factor
for cancer and treatment toxicity, recent evidence suggests mild obesity is related to better outcomes, with obese
cancer patients showing better responses to treatment when compared to lean cancer patients. This phenomenon is
termed obesity paradox and has been reported in diferent types and stages of cancer. The mechanisms underlying
this paradoxical relationship between obesity and cancer are still not fully described but point to systemic altera‑
tions in metabolic ftness and modulation of the tumor microenvironment by obesity-associated molecules. Obesity
impacts the response to cancer treatments, such as chemotherapy and immunotherapy, and has been reported as
having a positive association with immune checkpoint therapy. In this review, we discuss obesity’s association to
infammation and cancer, also highlighting potential physiological and biological mechanisms underlying this asso‑
ciation, hoping to clarify the existence and impact of obesity paradox in cancer development and treatment. - 中文關鍵字:
- 英文關鍵字: Obesity, Cancer, Immunotherapy, Adipose tissue, Infammation