- 作者： 王俊秀; 李維誠; 陳瑩霖; 顏全敏; 郭謨; 張甘楠
- 作者服務機構： 國立中興大學獸醫系; 私立高雄醫學院寄生蟲學科; 國立屏東農業專科學校獸醫系
- 中文摘要：
追?調查日月潭水社村養豬戶，結果中華肝吸蟲的陽性率為30.4%，其他漁牧綜合經營地
區的雲林縣口湖地區、苗栗縣轄內各鄉鎮的養豬戶所調查結果，發現雲林縣口湖地區有陽性寄生
母豬的存在。南部地區收集學生及教職員工的糞便檢查結果，教職員工的感染較學生為重。
肉眼上可見到肝表面有許多黃白點，肝臟切面可見嚴重的膽管壁增厚現象，膽管腔內充滿較
黏稠的膽汁，並可以檢出蟲體，組識切片下，可見到膽管上皮細胞極度增生，伴有明顯的炎症細
胞浸潤（尤以嗜酸性球為主），有慢性膽管炎、膽管擴大，腔內可見蟲體的斷面，肝小葉間隔的
纖維組織異常增生，間隔擴大，膽管附近的肝小葉呈現壓迫性萎縮。
感染豬的白血球數於第2週由正常平均值8,200/mm 上升至18,200/mm ，而於第3～5週
間達到最高值（22,800/mm ），其後稍為下降，直到第8週，其值仍為15,600/mm ，此表示感染
豬於第2週即有發炎的情形，白血球中的嗜酸性球在第3週有顯著上升（由13%上升至39%）
，而後於第4週恢復正常，血清鹼性磷酸（serum alkaline phosphatase）於第2週間即顯著上
升（由正常之96 KA單位上升至156 KA單位），此值一直維持到試驗終了，此顯示膽汁的鬱
滯，原因乃由於膽管的堵塞，然血清中的膽紅素量（bilirubin）未有顯著上升，即膽管並未完全
受到蟲體的堵塞，至於A/G, GOT, GPT均無顯著的變動，即肝細胞並未受到損失。
s - 英文摘要： 1. Epidemiological survey in several areas In a survey on the parasitism in livestockand man by the zoonotic clonorchiasis conduct-ed in epidemic areas, i.e., Sun Moon Lake,Yun-Lin and Miao-Li countryside, on stoolexaminations, 7 of 23 pigsties (30.4%) examinedshowed positive for clonorchis eggs at Shui-She Village near Sun Moon Lake. In Ko-Who District, Yun-Lin, there is a po-sitive case among breeder sows. Examination of adults and students stools,the result of egg-count showed that in olderages (staffs) the intensity of clonorchis infectionis higher than that in youths (students).2. Pathological change of liver The gross lesion was limited to the liversof the experimental pigs. Multiple yellowishfoci were scattered on the liver. On cut surface,enlargement of bile ducts was noticed. Thereare large amount of concentrated bile and lotsof adult worms within the lumen. Histopa-thologically, chronic chollangitis was the pro-minent change. Glandular hyperplasia of bileducts was accompanied with marked eosinophilinfiltration. In addition, large amount of connec-tive tissue was infiltrated around the affectedbile ducts of the interlobular space of liver.3. Pathological change of the swine hematology and liver function A great increase in WBC count from normalvalue of 8200/mm to 22800/mm was encoun-tered in the second week of the infection, andsuch a high value of WBC count remainedconstant up to the fifth week. Also, eosinophilsamong WBC drastically increased in its percen-tage-from 13% to 39%, but it declined quicklyto normal range in the fourth week. It signifiedthat inflammation started to take place at theearly time of infection. Serum alkaline phos-phatase increased significantly from 96 to 156 KAunit from the second week till the end of thisexperiment. Yet serum bilirubin did not increaseits volume conspicuously. Thus, the bileductwas not obstructed completely. There was nosignificant change in A/G ratio or GOT andGPT enzymes in serum. So the liver cell seemednot to be damaged to a significant level.4. Medical treatment trial in men After oral administration of Praziquantel-25 mg/kg, thrice a day for 2 days, nearly allthe fecal egg counts of patients turned nil afterthe 28th day of initial treatment. No specificside effect was observed.
- 中文關鍵字： --
- 英文關鍵字： --
