- 作者: Lok-Hi Chow; Eagle Y.-K. Huang; Shung-Tai Ho. Shen-Kou Tsai Pao-Luh Tao
- 作者服務機構: Graduate Institute of Mediccal Sciences, and Departments of Pharmacology and Anesthesiology, National Defense Medical Center, and Department of Anesthesiology, Tapei Veterans General Hospital and National Yang-Ming Universitry School of Medicine, Taipei Taiwan, ROC
- 中文摘要: --
- 英文摘要: Morphine is a strong and widely used opioid analgesic inpain management, but some adverse effects limit its clin-ical use at high doses. The clinically available non-opioidantitussive, dextromethorphan(DM)can potentiate theanalgesic effect of morphine and decrease the dose ofmorphine in acute postoperative pain.However, themechanism underlying this synergistic phenomenon isstill not clear. To examine if the potentiation by DMoccurs through the descending pain-inhibitory path-ways, ketanserin(a 5-HT2 receptor antagonist) and yo-himbine(an -adrenergic receptor antagonist) were em-ployed and found to have no significant effect on thepotentiation by DM.Using local delivery of drugs in ratsin the present study, potentiation of morphine-inducedantinociception by DM was observed via both intrathecaland intracerebroventricular routes, suggesting that bothspinal and supraspinal sites are involved.This suggeststhat the potentiation of morphine-induced antinocicep-tion by DM is not mediated by the serotoninergic oradrenergic descending pain-inhibitory pathways.Thepresent results are consistent with findings in clinicalstudies, which showed that DM can effectively decreasethe consumption of morphine in patients suffering frompain.Since DM has excellent clinical potential as a syner-gistic agent with morphine, further investigating andclarifying the possible pharmacological mechanism ofDM are of great importance for future studies.
- 中文關鍵字: --
- 英文關鍵字: --