- 作者: Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng and Euphemia Leung
- 作者服務機構: 1. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, No. 1 University Road, Tainan, Taiwan 2. Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3. National Institute of Cancer Research, National Health Research Institutes (NHRI), Tainan, Taiwan 4. Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand 5. Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Symonds Street, Auckland, 1010, New Zealand
- 中文摘要:
- 英文摘要:
X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these molecules has widely been shown to cause embryonic defects and to promote tumorigenesis in human. Besides the anti-apoptotic functions, recent discoveries have revealed that XIAP, survivin, and BRUCE also exhibit regulatory functions for autophagy in cells. As the role of autophagy in human diseases has already been discussed extensively in different reviews; in this review, we will discuss the emerging autophagic role of XIAP, survivin, and BRUCE in cancer cells. We also provide an update on the anti-apoptotic functions and the roles in maintaining DNA integrity of these molecules. Second mitochondria-derived activator of caspases (Smac) is a pro-apoptotic protein and IAPs are the molecular targets of various Smac mimetics currently under clinical trials. Better understanding on the functions of XIAP, survivin, and BRUCE can enable us to predict possible side effects of these drugs and to design a more “patient-specific” clinical trial for Smac mimetics in the future. - 中文關鍵字:
- 英文關鍵字: Autophagy, Apoptosis, BRUCE, IAP, Survivin, Smac, XIAP