- 作者: Mohamed S. A. El-Gaby*, Jehane A. Micky, Nadia M. Taha and Marwa A. M. Sh. El-Sharief
- 作者服務機構: Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524, Egypt
- 中文摘要: Thiophosgenation of sulfonamides 1a-c in the presence of dilute HCl at room temperature furnished the isothiocyanatosulfonamides 2a-c and treatment with aromatic amines gave 1,3-disubstituted thioureas 3a,b. Also, interaction of two molecules of 2c with 1,4-phenylenediamine yielded the novel bisthiourea 4. Cyclocondensation of 2 with ortho amino carboxylic acid compounds such as anthranilic acids 8, 5-amino-1-phenyl-pyrazol-4-carboxylic acid 9 and 4,5,6,7-tetrahydro-2-amino-benzo[b]thiophene-3-carboxylic acid 10 furnished the fused thiopyrimidines 11a-d, 12 and 13, respectively. 2-Anilinobenzoazole derivatives 15a-c, 16a,b and 17a,b were obtained through cyclocondensation of 2 with 1,2-dinucleophiles.
- 英文摘要: --
- 中文關鍵字: Thiourea; Hydrazine; Fused pyrimidine benzoazole; Sulfonamide; Antimicrobial activity.
- 英文關鍵字: Thiourea; Hydrazine; Fused pyrimidine benzoazole; Sulfonamide; Antimicrobial activity.