- 作者: Dar-In Tai SUn-Lung Tsai Tse-Ching Chen Sing Kailo Ya-Hui Chang Yun-Fan Liaw
- 作者服務機構: Liver Research Unit and Department of Pathology, Charng Gung Memorial Hospital and Chang Gung University, College of Medicine Taipei, Taiwan, ROC; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
- 中文摘要: --
- 英文摘要: Tumor necrosis factor (TNF) plays a role in the pathogen-esis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The difference in the cytokine responses betweenhepatitis B virus (HBV) and hepatitis C virus (HCV) infec-tions may have implications in the pathogenesis of thesediseases. We performed a comparative studyto examinethe possible differences in the TNF-TNF receptor (TNFR)response between CHB and CHC. We studied the cyto-kine levels of 38 patients with CHB, 40 patients with CHCand 9 patients with dual hepatitis B and C, and comparedthem with the baseline levels of 12 healthy controls. Theplasma levels of TNF- , interferon- , interleukin (IL)-2,IL-4, IL-10 and soluble TNFR-1 and 2 (sTNFR-1 and 2)were quantified by enzyme-linked immunosorbent as-says. The expression of TNFR-1 and 2 in liver tissues wasexamined in 30 cases of CHB and 15 cases of CHC bysemiquantitative reverse transcription polymerase chainreaction. The results showed that sTNFR-1 levels corre-lated with liver inflammation in all patients, whereas thiscorrelation was not found with sTNFR-2 or other cyto-kines. Liver inflammation indicators were higher inHCV RNA+ than in HCV RNA- CHC. Most significantly,sTNFR-1 levels correlated with liver inflammation inCHB, but not in CHC. However, the expression of TNFR-1and 2 in liver was similar between CHB and CHC. Thesefindings suggest that the TNFR signal transduction path-way is modulated differently in HBV and HCV infection.
- 中文關鍵字: --
- 英文關鍵字: Hepatitis B virus. Hepatitis c virus. Histology activity index. Tumor necrosis factor. Tumor necrosis factor receptor