- 作者: Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya
- 作者服務機構: 1. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan 2. Department of Translational Research for Extracellular Vesicles, Tokyo Medical University, 6-7-1 Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
- 中文摘要:
- 英文摘要:
Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast cells, immune cells, and endothelial cells, to create a cancer microenvironment for their progression. Extracellular vesicles (EVs) are small vesicles that can be secreted by most types of cells and play an important role in cell-to-cell communications via transferring bioactive cargos, including variable RNAs, such as microRNAs (miRNAs), to recipient cells. miRNAs are a class of small noncoding RNAs that posttranscriptionally regulate gene expression. The transfer of them to recipient cells influences the metastatic process of primary tumors. In this review, we summarize the function of miRNAs packaged in EVs in cancer metastasis and discuss the clinical utility of miRNAs in EVs. - 中文關鍵字:
- 英文關鍵字: Cancer metastasis, microRNA, Extracellular vesicle, Microenvironment