• 作者： 賴福明; 陳珮; 古曉娟; 李美璇; 張淑緘; 張子明; 劉紹興
• 作者服務機構： 三軍總醫院一般外科; 國防醫學院公共衛生研究所; 國防醫學院生化學系
• 中文摘要： 利用病例對照研究方法探討胎次、哺乳與乳癌之關係，114名新診斷乳癌的女性病例與年齡配對的228名對照組比較之研究結果發現生產大於三次、初次生產年齡小於30歲及哺乳超過三年的婦女有較低的乳癌危險性。經校正氏族和停經與否，生產大於三次及初次生產年齡小於30歲的婦女仍有顯著較低的乳癌危險性，而哺乳時間則與乳癌無統計相關。胎次與乳癌的相關性經校正初次生產年齡後仍呈顯著相關，表示胎次與初次生產年齡有獨立的作用。經校正哺乳時間，胎次與初次生產年齡仍與乳癌呈顯著相關，此亦表示胎次及初次生產年齡的保護作用不受哺乳因素影響。
• 英文摘要： A hospital-based case-control study was designed herein to investigate the relationship betweenparity, breast feeding and breast cancer in Taiwan. Reproductive histories of patients with breast cancerconfirmed by either pathology or cytology were assessed by questionnaire and compared with age-matchedhealthy controls. One hundred and fourteen cases and 228 age-matched controls were recruited for thisstudy. According to those results, women having had more than three full-term pregnancies, age at firstfull-term pregnancy younger than 30, and breast feeding for more than 3 years displayed significantlyprotective effects against breast cancer. Following adjustment for ethnicity and menopausal status, womenwith more than three full-term pregnancies and younger than 30 years old at first full-term pregnancy had adecreasd risk of breast cancer. However, duration of breast feeding was not related to breast cancer, afteradjustment for ethnicity and menopausal status. The effect of number of full-term pregnancies on the riskof breast cancer was found to be independent of the effect of age at first full-term pregnancy. Moreover,the effect of age at first full-term pregnancy and number of full-term pregnancies was also independent ofthe effect of breast feeding.
• 中文關鍵字： breast cancer; parity; breast feeding; age at first full-term pregnancy.
• 英文關鍵字： --