- 作者: 陳清玉,陳信志,簡偉明
- 作者服務機構: Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan, R.O.C.
- 中文摘要: A series of 4-[2-(alicyclic-[1,2,4]oxadiazol-3-yl)phenoxy]-butyric acids were synthesized from N-hydroxy-2-isopropoxy benzamidine in 4 steps with good yields. These [1,2,4]oxadiazoles are novel platelet aggregation inhibitors preventing human platelet aggregation induced by thromboxane derivative U44,619 and adenosine diphosphate. A structure-activity-relationship study revealed that the potency for these 5-oxadiazoles increases with the increase in the ring size of the alicylic rings. Derivative 8f may be useful as a template for the design of more potent anti-platelet agents.
- 英文摘要: --
- 中文關鍵字: Platelet inhibitors; 1,2,4-Oxadiazoles.
- 英文關鍵字: --