- 作者: 王義烽; 柯黃盛; 李佩潔; 黃麗月
- 作者服務機構: Institute of Pharmacentical Sciences, Kaohsiunung Medical College, Kaohsiung, Taiwan 800, R.O.C.
- 中文摘要: (S)-Propranolol, [1-isopropylamino-3-(1-naphthoxy)-2-propanol], which possesses important .beta.-adrenergic blocking activity, has been synthesized by a chemicoenzy-matic approach. The 2S-absolute configuration was created by the enzyme-mediated asymmetric hydrolysis of the (.plmin.)-2-acetoxy-1-chloro-3-(1-naphthoxy)-2-naphthoxy-2-propanol. The enzymatically produced chiral intermediate was then chemically converted to optically pure (S)-propranonol.
- 英文摘要: --
- 中文關鍵字: (S)-Propranolol; chemicoenzymatic.
- 英文關鍵字: (S)-Propranolol; chemicoenzymatic.