- 作者: 沈宗瀛
- 作者服務機構: Chemistry Dept., Univ. of Virginia, Charlottesville, Virginia, U.S.A.
- 中文摘要: Following the discovery of salicylates and its conversion to aspirin, natural products research has provided many promising leads for further modification as anti-inflammatory and analgesic agents. Recent studies have focused on biosynthesis inhibitors of eicosanoids and receptor antagonists of the platelet activating factor, including a new class of dual functional inhibitors derived from neolignans. The highly potent analgesic alkaloid epibatidine from the frog skin has been synthesized and recharacterized as a very strong acetylcholine nicotinic receptor agonist. Some novel epibatidine analogs have shown promise as potential CNS drugs and research probes for clarifying the anti-addictive property of the African alkaloid ibogaine.
- 英文摘要: --
- 中文關鍵字: Natural Product; Anti-Inflammatory; Analgesic Agent; Arachidonic Acid; Cyclooxygenase Inhibitor; Antiaddictive Effect
- 英文關鍵字: 天然物;抗炎;止痛藥;二十酸四稀酸;環氧抑制劑;抗加成效應