- 作者: Si Yun Shu
- 作者服務機構: Institure for Neurosclenec of the First Military Medical University, Zhu-jiang Hospital, Guangzhou, Chine
- 中文摘要: --
- 英文摘要: The margina division (MrD) is a pan-shaped subdivisionin the caudal margin of the neostriatum newly discov-ered in the brains of the rat, cat, monkey and humans. Avariety of intensely expressed neuropeptides and mono-amines and their receptors were identified in the fibers,terminals and neuronal∣somata in the MrD with immuno-histochemical and patch clamp methods.The MrD wasshown to be involved in learning and memory by dou-ble-blind studies of Y-maze learning and long-term po-tentiation in rats. c-Fos expression and tract-tracing tech-niques with immunoelectronmicroscopy indicated thatthe MrD is a new component of the limbic system and isa key linking area between the limbic system and thebasal nucleus of Meynert. Functional magnetic reso-nance image (fMRI) studies illustrated that the MrD andthe prefrontal cortex are involved in digital workingmemory in the human brain.A cerebral hemorrhagecase report confirmed the findings with fMRI.In conclu-sion, based on the position of the MrD, its advanceddevelopment in higher mammalian brains, abundantblood supply and diverse connections with other memo-ry-related structures, MrD is likely to be an importantsubcortical∣center of learning and memory.
- 中文關鍵字: --
- 英文關鍵字: Learning and memory. Immunohistochemistry. c-Fos. Cognitive funcition. Long-term Potentiation. Patch clamp. Functional magnetic resonance image. Cerebral hemorrhage. Hippocampus. Striaum