• 作者： 田憲儒 ; 賴榮豐 ; 李耀坤 等
• 作者服務機構： Dept. of Chemistry, National Chengkung Univ., R.O.C.
• 中文摘要： A new method to prepare 3,3'-ethylenebissydnone (40%), 3,3'-tetramethylenebissydnone (37%) and 3,3'- hexamethylenebissydnone (43%) from the corresponding alkylene diamine with paraformaldehyde and potassium cyanide were investigated.
  Some new bissydone: 3,3'-trimethylenebissydnone (6%), 3, 3'-(4,4'-diphenyl)bissydnonylmethane (9%) and 3,3'-(4, 4'- diphenyl)bissydnonyl ether (28%) were synthesized from the corresponding diamine, paraformaldehyde, sodium bisulfite and potassium cyanide.
  Biological test of 3,3'-(4, 4'-diphenyl) bissydnonylmethane shows significant response for coronary dilation test, inhibition of collagen induced platelet aggregation and moderate cardiotropic response. 3,3'-(4, 4,- Diphenyl)bissydnonyl ether also shows inhibition of collagen induced platelet aggregation and moderate cardiotropic response.
• 英文摘要： --
• 中文關鍵字： Bissydnone; Coronary Dilation Test; Inhibition; Platelet Aggregation; Cadiotropic
• 英文關鍵字： 雙斯德酮；冠狀動脈擴張試驗；抑制作用；血小板凝集；雙雪梨酮