• 作者： 朱邦猷; 崔靜亞; 丁令旦
• 作者服務機構： 國防醫學院生物形態學研究所
• 中文摘要： 肝癌病人常伴有肝硬化，故肝癌之發生與肝硬化似有若干值得研究之因果關係。本實驗採用三十一例壞死後肝硬化之肝穿刺標木及用四氯化碳在大白鼠誘發之肝硬化之肝標太，作光學顯微 鏡及電子顯微鏡之研究。 人與動物肝硬化的電子顯微鏡下變化，大致相同。人類肝細胞之核漿變濃不均，內質網之增加及膨脹及核糖體、粒線體之增加等，乃表示細胞活動性之增加。此外，細胞局部退行性變化，可能係致癌毒素或病毒之刺激而引起。此等變化顯示肝硬化之肝細胞經常處於動蕩不定之環境中 ，日久難免發生細胞突變而演變為肝癌。 大白鼠可用作肝癌研究之材料。本實驗之結果，將可供電子顯微鏡研究肝癌之對比。
• 英文摘要： Very high incidence of hepatoma associ-ated with cirrhosis of liver, especially post-necrotic cirrhosis, is well documented. Itis thought that the genesis of hepatoma isof 22 rats with cirrhosis of liver induced byCCl injection were studied by electron micr-oscopy and light microscopy. The liver cells in cases of postnecroticcirrhosis showed remarkable EM changesrepresenting increase in functional activitiesand regressive changes. It is conceivable thatthese liver cells might be easily stimulatedor being stimulated by either hepatotoxic a-closely related to the occurrence of cirrhosisof liver. Specimens of liver needle biopsy from31 cases of postnecrotic cirrhosis and liversgents or viruses and eventually evolve intouncontrolled cancer cells through mutationor some unknown processes. This is an in-teresting problem and much more work isto be done. The electron microscopic findings inthis study are good for comparison in thecoming studies of ultrastructural changesof the hepaterna.
• 中文關鍵字： --
• 英文關鍵字： --