- 作者: 李明,文麗榮,王書文,齊文英,張秀麗,楊華錚
- 作者服務機構: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
- 中文摘要: Two series, totaling twelve, of new compounds, ethyl 1-aroyl/(aroylmethyl)-5-methyl-3-methylthiopyrazole-4-carboxylates (5/6), have been synthesized via highly regioselectively acylation and alkylation reactions of ethyl 3-methyl-5-methylthio-1H-pyrazole-4-carboxylate (2a) with aroyl chloride (3) and eco-friendly reagents alpha-tosyloxysubstituted acetophenones (4), respectively, and a green protocol has been developed. The acylation reactions were carried out under ultrasound irradiation, and the alkylation reactions were under microwave irradiation and ultrasound irradiation, respectively. Conventional reaction conditions, as well as the use of alpha-bromosubstituted acetophenone (4¢) have also been applied in the synthesis of some randomly selected compounds in both series and have generated identical compounds correspondingly. Unexpected structures of compounds were unambiguously determined by X-ray crystallographic analysis.
- 英文摘要: --
- 中文關鍵字: Pyrazole; Regioselectivity; X-ray crystallographic analysis; 2D NMR.
- 英文關鍵字: --