• 作者： 鍾來如; 楊蘭平; 江文秀; 林犁花
• 作者服務機構： 台中市榮民總醫院台中分院血液科; 台北市榮民總醫院血液科
• 中文摘要： 本文報告三例成人慢性骨髓性白血病(CML)呈現牽涉 3 或 4 個染色體之繁複費城染色體轉位者。病例一為一61歲男性，在本病之慢性期，其骨髓細胞染色體核型為46,XY,t(3;9;15;22)。病例二為一26歲即將臨產婦女，其染色體呈現45,XX,-7,t(9;17;22)。在其右肩、胸壁及乳房發現多發性腫瘤，經切片檢查證實為骨髓芽球症。此婦女稍後自然產出一正常嬰兒。病例三為一24歲女性，罹患原發性血小板增多症一年後，呈現典型CML病況，其染色體核型為46,X,inv(X),t(9;11;22)。在本系列39例國人成人CML中，發現三例繁複費城染色體轉位情形，因此，其發生率約為7.7%。
• 英文摘要： Three cases of adult chronic myelocytic leukemia (CML) with complex Philadelphia chromosome(Ph ) translocations involving 3 or 4 chromosomes were reported. Case 1 was a 61-year-old man whoexhibited a karyotype of 46,XY,t(3;9;15;22) during his chronic phase. Case 2 was a 26-year-old nearlyfull-term pregnant woman who showed a karyotype of 45,XX,-7,t(9;17;22) and multiple masses over theright shoulder, upper chest wall and right breast. The biopsy study of the local masses disclosed a pictureof myeloid blastosis. In spite of the illness, she delivered a normal baby. Case 3 was a 24-year-old collegegirl who suffered from primary thrombocythemia for one year then developed a full-blown CML with akaryotype of 46,X,inv(X),t(9;11;22). The frequency of complex Ph translocation in our series of 39adult CML cases was 7.7%.
• 中文關鍵字： --
• 英文關鍵字： --