- 作者： 蘇美貴; 曹之憲; 陳介甫; 韓偉
- 作者服務機構： 國立陽明醫學院藥理及生理學科
- 中文摘要：
本研究是探用一種自清醒大白鼠之胃?管收集胃液的新方怯以探討carbenoxolone及cimetidine對正常動物及對接
受有胃酸分泌增進物之動物的胃酸分泌之影響。以胃洗出液的pH值定胃液酸度。
結果發現，在正常動物，cimetidine大大的增加胃液pH值，但carbenoxolone對胃液酸度無影響。我們也同時發
現cimetidine能很有效的對抗histamine，methacholine及pentagastrin所刺激之胃酸分泌。同樣的carbenoxolone對以
上三種胃酸分泌增進劑之作用無顯著影響。由此可見cimetidine及carbenoxolone兩藥之抗胃潰瘍的作用機轉必不相同 - 英文摘要： The effects of carbenoxolone and cimetidine on spontaneous and induced gastric acid secretionwere investigated in conscious rats with chronic stomach cannulas. A modified method was used to collectgastric acid secretion, and its acidity was determined by pH measurements. Under normal condition, it was found that gastric pH was markedly increased by cimetidine but notby carbenoxolone. Furthermore, gastric acid secretion induced by histamine, methacholine or pentagastrinwas significantly antagonized by cimetidine but not by carbenoxolone. These differential actions ofcarbenoxolone and cimetidine on gastric acid secretion suggest that the antiulcer activities of these twodrugs are exerted through different mechanisms.
- 中文關鍵字： --
- 英文關鍵字： --
