- 作者: Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang & Wai Kit Chu
- 作者服務機構: 1.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China 2.Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China 3.Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China
- 中文摘要:
- 英文摘要:
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays
critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly
regulated, where post-translational modifcations (PTMs) play crucial roles, including phosphorylation, ubiquitination,
SUMOylation, acetylation and methylation. Most PTMs on pRb are reversible and can be detected in non-cancerous
cells, playing an important role in cell cycle regulation, cell survival and diferentiation. Conversely, altered PTMs on
pRb can give rise to anomalies in cell proliferation and tumourigenesis. In this review, we frst summarize recent fnd‑
ings pertinent to how individual PTMs impinge on pRb functions. As many of these PTMs on pRb were published
as individual articles, we also provide insights on the coordination, either collaborations and/or competitions, of the
same or diferent types of PTMs on pRb. Having a better understanding of how pRb is post-translationally modulated
should pave the way for developing novel and specifc therapeutic strategies to treat various human diseases. - 中文關鍵字:
- 英文關鍵字: Retinoblastoma, Phosphorylation, Ubiquitination, SUMOylation, Acetylation, Methylation