• 作者： 魏如東; 張勝祺; 鄭美惠
• 作者服務機構： 國立陽明醫學院生化研究所
• 中文摘要： 利用Amberlite XAD-2 樹脂抽取水樣品中致突變之有機物質，然後依序以
  丙酮、丙酮與正己?（15：85, v/v）洗下樹脂上吸附之有機物質，進行Salmonella/
  microsome system之致突變性試驗，在檢測之臺北市74件自來水樣品中，不曾測
  出含有致突變物質，而8件地下水樣品中有一件略具致突變能力。
  外雙溪河水經由氯化作用後，不需 S9 之致活即能引起細菌 TA 100 之突變
  ，且隨含氯量之增加，其致突變能力亦增加，惟蒸餾水經氯化作用後，不引起細菌
  之突變。另外，河水氯化前或氯化後經食沸，其致突變能力顯著降低。r
• 英文摘要： We have studied the mutagenicityof the tap water and ground water ofthe Taipei area. Water samples. 20,were passed through XAD-2 resin col-umn which was later eluted with acetoneand then a mixture of acetone and n-hexane (15:85, v/v). The eluents wereevaporated and the dry residue subjectedto Ames test. Seventy-four tap watersamples showed non-mutagenicity forSalmonella typhimurium TA 98 andTA 100. One out of eight samples fromground water showed a weak mutagenicactivity with a dose response. The extract from chlorinated riverwater showed mutagenic activity onTA 100 without S9 activation. Themutagenicity was proportional to thedose of chlorination. However, theextract from chlorinated distilled waterhad no mutagenic activity. When riverwater was boiled before or after chlori-nation, the mutagenicity was markedlydecreased.
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