- 作者: 王瑞駪 ; 王愛紅 ; 康英淑 ; 李志堅 ; 王博恩
- 作者服務機構: Natural Sciences Center, State University of New York
- 中文摘要: Monofunctional, bifunctional and trifunctional poly-2'-(2,4-dinitrophenyl)-oligoribonucleotides have been designed and synthesized as inhibitors of retroviruses. These compounds are membrane-permeable, ribonuclease-resistant, and apparently mutation- insensitive inhibitors of reverse transcriptases. These inhibitors have been tested for the treatment of murine leukemia as an animal model related to AIDS. Although the monofunctional inhibitor is already 100% effective for the treatment of murine leukemia, its efficacy can be increased by two orders of magnitude by introducing antisense sequences in the nucleotide backbone so that the resulting multifunctional inhibitor can also disrupt the synthesis of specific viral proteins. The entropy advantage of multifunctionality in the design of antiviral agents is discussed.
- 英文摘要: --
- 中文關鍵字: Poly-Dnp-Oligonucleotide; Retrovirus; Reverse Transcriptase; Human Immunodeficirncy Virus (Hiv); Aids; Inhibitor
- 英文關鍵字: Poly-DNP-寡核酸;反轉錄病毒;反轉錄;人類免疫缺乏病毒;愛滋病;抑制劑