- 作者: 何玉文
- 作者服務機構: Department of Textile Engineering, Nanya Institute of Technology, Chung-Li, Taiwan 32034, R.O.C.
- 中文摘要: Cyclization of 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine 4 with excess of 85% hydrazine hydrate afforded the 3-amino-4-methyl-6-phenylpyrazolo[3,4-d]pyrimidine 5, which can react with appropriate Mannich base derivatives 13a-c and chalcones 27a,b to yield the corresponding 6,8-disubstituted 7,8-dihydropyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidines 15a-c and 30a,b, respectively. On the other hand, the 6,7,8-trisubstituted pyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidine derivatives 8a-g, 20a-e, 36 and 38 were obtained by treatment of compound 5 with appropriate 1,3-diketones 6a-g, 3-dimethylamino-1-(substituted)prop-2-enones 18a-e, 3-aminocrotononitrile 3, and ethoxymethylenemalononitrile 37 under acidic condition, respectively.
- 英文摘要: --
- 中文關鍵字: 5-Cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine; 3-Amino-6-phenylpyrazolo[3,4-d]pyrimidine; 6,8-Disubstituted 7,8-dihydropyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidines; 6,7,8-Trisubstituted pyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidines.
- 英文關鍵字: 5-Cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine; 3-Amino-6-phenylpyrazolo[3,4-d]pyrimidine; 6,8-Disubstituted 7,8-dihydropyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidines; 6,7,8-Trisubstituted pyrimido[2,3:4,3]pyrazolo[1,5-a]pyrimidines.