- 作者: Elizabeth A. Rich
- 作者服務機構: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, Ohio, USA
- 中文摘要: --
- 英文摘要: The lung is prominently afflicted during the course of HIV-1 disease by both infectious and noninfectious complications. Direct or indirect effects of HIV-1 are likely central to the pathogenesis of these complications. Thus, any changes in viral load locally would negatively impact on the lung. This review focuses on the endogenous influences (immune effector cells, surfactant) and the exogenous factors (including infections such as tuberculosis and noninfectious exposures like cigarette smoke) that may contribute to activation or inac-tivation of HIV-1 in the lung.
- 中文關鍵字: --
- 英文關鍵字: HIV-1 ; Lung; Activation; Alveolar macrophages ; Alveolar lymphocytes ; Cigarette smoke ; Tuberculosis ; Surfactant