- 作者: --
- 作者服務機構: Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
- 中文摘要: In this study, certain 3-substituted styrylquinoxalin-2(1H)-ones (2a-d) and their 2-chloro (3a-d) and 2-piperazinyl derivatives (4a-g) were synthesized from 3-methylquinoxalin-2(1H)-one (1). In addition, a series of 1-alkyl-3-substituted styrylquinoxalin-2(1H)-ones (5a-d) was also prepared. Moreover, 3-(N2-arylidenehydrazinocarbonyl)quinoxalin-2(1H)-ones (8a-c) as well as their cyclized oxadiazolinyl derivatives (9a-c) were prepared from 3-hydrazinocarbonylquinoxalin-2(1H)-one (7). Furthermore, 3-(5-substituted thio-1,3,4-oxadiazol-2-yl)quinoxalin-2(1H)-ones (11a-c) and (12a-c) were obtained from the intermediate compound (10) - previously obtained via cyclization of (7) with CS2. Likewise, 3-(5-oxo-4,5-dihydro-(1,3,4-oxadiazol-2-yl)quinoxalin-2(1H)-one (13), 3-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-quinoxalin-2(1H)-one (14) and its 2-chloro derivative (15) were prepared from 3-hydrazinocarbonylquinoxalin-2(1H)-one (7). Some of these derivatives were evaluated for antimicrobial activity in vitro and some of the tested compounds showed antibacterial or antifungal activity.
- 英文摘要: --
- 中文關鍵字: 2-Piperazinyl-3-styrylquinoxalines; 3-Oxadiazolylquinoxalin-2(1H)-one; Antimicrobial activity.
- 英文關鍵字: --