- 作者: 劉振倫,張天燦,吳叔旻,江惠震
- 作者服務機構: Institute of Biotechnology, National Dong-Hwa University, Shou-Feng, Hualien Hsien 974, Taiwan, R.O.C.
- 中文摘要: The dissolved concentrations of ampicillin anhydrate, ampicillin trihydrate, and their mixtures were experimentally determined. For 100% ampicillin anhydrate and 100% ampicillin trihydrate cases, the dissolved concentration (mg/mL) was equal to the total amount of 100% ampicillin anhydrate and 100% ampicillin trihydrate in 1 mL solution up to the solubility (10.8 mg/mL) of 100% ampicillin anhydrate and the solubility (5.4 mg/mL) of 100% ampicillin trihydrate. For an ampicillin anhydrate to ampicillin trihydrate mixture ratio of 75:25, the relationship between the dissolved concentration and the total amount of the mixture in 1 mL solution was the same as the 100% ampicillin anhydrate case. As for the ampicillin anhydrate to ampicillin trihydrate mixture ratios of 50:50 and 25:75, the total solubility of 10.8 mg/mL could be reached at greater amounts of the mixtures. A model of diffusion-controlled dissolution rate mechanism with two experimental solubilities, 10.8 mg/mL for ampicillin anhydrate and 5.4 mg/mL for ampicillin trihydrate, was used to successfully interpret the solubility data.
- 英文摘要: --
- 中文關鍵字: Ampicillin anhydrate; Ampicillin trihydrate; Solubility.
- 英文關鍵字: --