• 作者： Bin Zhang, Wei Kian Sim, Tang-Long Shen & Sai Kiang Lim
• 作者服務機構： 1.Center for Biotehnology, National Taiwan University, Taipei, 10617, Taiwan 2.Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, 10617, Taiwan 3.Department of Surgery, YLL School of Medicine, National University of Singapore (NUS), Lower Kent Ridge Road, Singapore, 119074, Singapore 4.Institute of Molecular and Cellular Biology, A*STAR, 8A Biomedical Grove, Singapore, 138648, Singapore 5.Paracrine Therapeutics Pte. Ltd., 10 Choa Chu Kang Grove #13-22 Sol Acres, Singapore, 688207, Singapore
• 中文摘要：
• 英文摘要：
  Extracellular vesicles (EVs) are tiny, lipid membrane-bound structures that are released by most cells. They play a vital role in facilitating intercellular communication by delivering bioactive cargoes to recipient cells and triggering cellular as well as biological responses. EVs have enormous potential for therapeutic applications as native or engineered exosomes. Native EVs are naturally released by cells without undergoing any modifications to either the exosomes or the cells that secrete them. In contrast, engineered EVs have been deliberately modified post-secretion or through genetic engineering of the secreting cells to alter their composition. Here we propose that engineered EVs displaying pathogen proteins could serve as promising alternatives to lipid nanoparticle (LNP)-mRNA vaccines. By leveraging their unique characteristics, these engineered EVs have the potential to overcome certain limitations associated with LNP-mRNA vaccines.
• 中文關鍵字：
• 英文關鍵字： EV-based protein vaccines, Extracellular vesicles (EVs), Exosomes, LNP-mRNA vaccines, Mesenchymal stem/stromal cell (MSC)