- 作者: Eun Jeong Park , Yoshikazu Yuki, Hiroshi Kiyono, Motomu Shimaoka
- 作者服務機構: epartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Mie , Japan
- 中文摘要: --
- 英文摘要: Integrins mediate leukocyte accumulation to the sites of inflammation, thereby enhancing their potential as an important therapeutic target for inflammatory disorders. Integrin activation triggered by inflammatory mediators or signaling pathway is a key step to initiate leukocyte migration to inflamed tissues; however, an appropriately regulated integrin deactivation is indispensable for maintaining productive leukocyte migration. While typical integrin antagonists that block integrin activation target the initiation of leukocyte migration, a novel class of experimental compounds has been designed to block integrin deactivation, thereby perturbing the progression of cell migration. Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship.
- 中文關鍵字: --
- 英文關鍵字: Integrin; Affinity; Activation; Deactivation; Leukocyte; Inflammation; Talin; Kindlin