- 作者: 林哲彥 ; 楊美惠
- 作者服務機構: 台南師範學院數理教育系
- 中文摘要: A series of fourteen anilide derivatives of ibuprofen were resolved on six chiral stationary phases (CSPs) derived from N-arylcarbamoyl derivatives of (S)- phenylglycine. Excellent chiral resolutions were achieved on these CSPs. The ionic-type CSPs showed better chiral recognition abilities than the corresponding covalent-type CSPs, and the CSP bearing two chiral centers has better performance than the CSPs bearing only one chiral center. The highest separation factor was achieved using the ionic- type CSP bearing two chiral centers for the resolution of the 3,5-dinitroanilide derivative of ibuprofen. This result is better than those reported in literature for the resolution of ibuprofen on the CSPs derived from amino acids. According to the chromatographic behaviors, the hydrogen bonding interaction, the .pi.-.pi. interactions provided by the phenyl groups in CSPs bearing one chiral center, and the phenylethylcarbamoyl moiety in CSPs bearing two chiral centers dominate the chiral recognition.
- 英文摘要: --
- 中文關鍵字: Ibuprofen; Enantiomeric Separation; Chiral Stationary Phase; Chiral Recognition Model; Phenylglycine
- 英文關鍵字: 艾普若芬;對映異構物分離;對掌固定相;對掌性辨認模式;苯基甘胺基酸